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{"id":2021,"date":"2019-12-12T09:43:07","date_gmt":"2019-12-12T09:43:07","guid":{"rendered":"https:\/\/www.senatormedical.se\/?p=2021"},"modified":"2019-12-12T09:43:18","modified_gmt":"2019-12-12T09:43:18","slug":"increase-of-survival-immunoresponse-enhancement-with-electrochemotherapy-in-lung-colorectal-cancer-in-mural-models-2019","status":"publish","type":"post","link":"https:\/\/www.senatormedical.se\/increase-of-survival-immunoresponse-enhancement-with-electrochemotherapy-in-lung-colorectal-cancer-in-mural-models-2019\/","title":{"rendered":"Increase of survival & immunoresponse enhancement with ElectroChemotherapy in Lung & Colorectal cancer in mural models-2019"},"content":{"rendered":"
Is an emerging treatment modality for cancer patients which can effectively reduce tumour burden and induce immunogenic cell death. Electrochemotherapy is most commonly used with bleomycin as the drug of choice, here we examine the efficacy of electrochemotherapy with cisplatin. Electrochemotherapy with cisplatin was found to effectively reduce tumour growth in a range of murine models and induce significant intratumoural recruitment of myeloid and humoral immune cells. Following the observations of immune system mobilisation, we have shown an ability of electrochemotherapy to reduce\u00a0metastatic potential\u00a0as determined by tumour burden in the lung, and to exert an\u00a0abscopal effect<\/a>\u00a0by reducing growth at distal untreated secondary tumours.<\/p>What drugs are being used most in ElectroChemotherapy? Bleomycin & Cisplatin \u2022 ECT with cisplatin is an effective form of therapy showing significant decrease in cancer cell growth\u00a0in vitro<\/em>\u00a0and\u00a0in vivo<\/em>.\u2022<\/p> \u2022 Immune cell mobilisation is visible locally and systemically following treatment.\u2022<\/p> \u2022 ECT with cisplatin may be useful in reducing the growth of distal untreated growth and controlling metastatic disease.<\/p> Read the entire article on this LINK<\/a><\/p> Reference: <\/p>Highlights<\/h2>
Cancer Letters<\/h2>